Tnfsf10

Function

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Post-translational modifications

Tyrosine phosphorylated by PKDCC/VLK.

Sequence Similarities

Belongs to the tumor necrosis factor family.

Tissue Specificity

Widespread.

Cellular localization

• Cell membrane
• Single-pass type II membrane protein
• Secreted
• Exists both as membrane-bound and soluble form.

Alternative names

CD253, Trail, Tnfsf10, Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL

Database links

swissprot:P50592 entrezGene:22035

Other research areas

• Oncology