Tnfsf12

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.

The soluble form derives from the membrane form by proteolytic processing.

Belongs to the tumor necrosis factor family.

Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.

• Cell membrane
• Single-pass type II membrane protein
• Tumor necrosis factor ligand superfamily member 12, secreted form
• Secreted
• Isoform TWE-PRIL
• Cell membrane
• Single-pass membrane protein

APO3L, DR3LG, UNQ181/PRO207, TNFSF12, Tumor necrosis factor ligand superfamily member 12, APO3 ligand, TNF-related weak inducer of apoptosis, TWEAK

• entrezGene:8742
• omim:602695
• swissprot:O43508

Proteins

Immuno-oncology

• Cardiovascular

27216Da