TNFSF12

Function

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.

Post-translational modifications

The soluble form derives from the membrane form by proteolytic processing.

Sequence Similarities

Belongs to the tumor necrosis factor family.

Tissue Specificity

Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.

Cellular localization

• Cell membrane
• Single-pass type II membrane protein
• Tumor necrosis factor ligand superfamily member 12, secreted form
• Secreted
• Isoform TWE-PRIL
• Cell membrane
• Single-pass membrane protein

Alternative names

APO3L, DR3LG, UNQ181/PRO207, TNFSF12, Tumor necrosis factor ligand superfamily member 12, APO3 ligand, TNF-related weak inducer of apoptosis, TWEAK

Database links

swissprot:O43508 omim:602695 entrezGene:8742

Other research areas

• Cardiovascular