Tnfsf12

Function

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion (By similarity).

Post-translational modifications

The soluble form is produced from the membrane form by proteolytic processing.

Sequence Similarities

Belongs to the tumor necrosis factor family.

Tissue Specificity

Widely expressed.

Cellular localization

• Cell membrane
• Single-pass type II membrane protein
• Tumor necrosis factor ligand superfamily member 12, secreted form
• Secreted

Alternative names

Tumor necrosis factor ligand superfamily member 12, TNF-related weak inducer of apoptosis, TWEAK, Tnfsf12

Database links

swissprot:O54907 entrezGene:21944

Other research areas

• Cardiovascular