TNFSF13

Function

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.

Post-translational modifications

The precursor is cleaved by furin.

Sequence Similarities

Belongs to the tumor necrosis factor family.

Tissue Specificity

Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

Cellular localization

• Secreted

Alternative names

CD256, APRIL, TALL2, ZTNF2, UNQ383/PRO715, TNFSF13, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand, TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1, TALL-2, TRDL-1

Database links

swissprot:O75888 omim:604472 entrezGene:8741

Other research areas

• Immunology & Infectious Disease