Tnfsf13b

Function

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.

Post-translational modifications

The soluble form derives from the membrane form by proteolytic processing.

Isoform 2 is not efficiently shed from the membrane unlike isoform 1.

Sequence Similarities

Belongs to the tumor necrosis factor family.

Tissue Specificity

Isoform 2 is expressed in many myeloid cell lines.

Cellular localization

• Cell membrane
• Single-pass type II membrane protein
• Tumor necrosis factor ligand superfamily member 13b, soluble form
• Secreted

Alternative names

CD257, Baff, Tnfsf13b, Tumor necrosis factor ligand superfamily member 13B, B-cell-activating factor, BAFF

Database links

swissprot:Q9WU72 entrezGene:24099

Other research areas

• Immuno-oncology