Tnfsf14
Function
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (By similarity).
Post-translational modifications
The soluble form derives from the membrane form by proteolytic processing.
Sequence Similarities
Belongs to the tumor necrosis factor family.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
- Tumor necrosis factor ligand superfamily member 14, soluble form
- Secreted
Alternative names
CD258, Light, Tnfsf14, Tumor necrosis factor ligand superfamily member 14