TNFSF14

Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (By similarity).

The soluble form derives from the membrane form by proteolytic processing.

Belongs to the tumor necrosis factor family.

• Cell membrane
• Single-pass type II membrane protein
• Tumor necrosis factor ligand superfamily member 14, soluble form
• Secreted

CD258, Light, Tnfsf14, Tumor necrosis factor ligand superfamily member 14

• entrezGene:50930
• swissprot:Q9QYH9

Proteins

Immuno-oncology

26338Da