ABIN3

Function

Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.

Tissue specificity

Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis, placenta, thyroid, uterus, prostate, skin and PBL.

Alternative names

• TNFAIP3-interacting protein 3
• A20-binding inhibitor of NF-kappa-B activation 3
• Listeria-induced gene protein
• ABIN-3
• TNIP3
• ABIN3
• LIND

Database links

• entrezGene:79931
• omim:608019
• swissprot:Q96KP6

Target type

Proteins

Molecular weight

38943Da