TNNI3K
Function
May play a role in cardiac physiology.
Involvement in disease
Cardiac conduction disease with or without dilated cardiomyopathy
CCDD
A cardiac disorder characterized by atrial tachyarrhythmia and conduction system disease. Some patients have dilated cardiomyopathy. CCDD inheritance is autosomal dominant.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Autophosphorylated.
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Tissue Specificity
Highly expressed in both adult and fetal heart.
Cellular localization
- Nucleus
- Cytoplasm
- Expressed at lower levels in the cytoplasm.
Alternative names
CARK, TNNI3K, Serine/threonine-protein kinase TNNI3K, Cardiac ankyrin repeat kinase, Cardiac troponin I-interacting kinase, TNNI3-interacting kinase