TNP1
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Sequence Similarities
Belongs to the nuclear transition protein 1 family.
Tissue Specificity
Expressed by spermatids (at protein level).
Cellular localization
- Nucleus
- Chromosome
- Loaded onto the nucleosomes of condensing spermatids.
Alternative names
Spermatid nuclear transition protein 1, STP-1, TP-1, TNP1