TNS4
Function
Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316).
Post-translational modifications
Proteolytically cleaved by caspase-3 during apoptosis.
Sequence Similarities
Belongs to the PTEN phosphatase protein family.
Tissue Specificity
Expressed at low levels in colon (at protein level) (PubMed:19214987, PubMed:19487278). Expressed in prostate and placenta (PubMed:12154022).
Cellular localization
- Cell junction
- Focal adhesion
- Cytoplasm
- Cytoskeleton
Alternative names
CTEN, PP14434, TNS4, Tensin-4, C-terminal tensin-like protein