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TNS4

Function

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.

Post-translational modifications

Proteolytically cleaved by caspase-3 during apoptosis.

Sequence similarities

Belongs to the PTEN phosphatase protein family.

Tissue specificity

Prostate and placenta. Down regulated in prostate cancer.

Cellular localization

  • Cell junction
  • Focal adhesion
  • Cytoplasm
  • Cytoskeleton

Alternative names

  • Tensin-4
  • C-terminal tensin-like protein
  • PP14434
  • CTEN
  • TNS4

Target type

Proteins

Molecular weight

76764Da