TOB1
Function
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).
Post-translational modifications
Phosphorylated on Ser and Thr residues.
Sequence Similarities
Belongs to the BTG family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Nucleus
- Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.
Alternative names
TOB, TROB1, TOB1, Protein Tob1, Transducer of erbB-2 1