Tor1aip1
Developmental stage
At 16 dpc, widely expressed with high expression levels in hippocampus and low levels in heart. In the spinal cord, expressed as early as 12 dpc until p21, the expression levels decrease in the adulthood (at protein level).
Function
Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.
Sequence Similarities
Belongs to the TOR1AIP family.
Tissue Specificity
Expressed in the spinal cord and liver (at protein level).
Cellular localization
- Nucleus inner membrane
- Single-pass membrane protein
Alternative names
Torsin-1A-interacting protein 1, Lamina-associated polypeptide 1B, LAP1B, Tor1aip1