TPH1
Function
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
Pathway
Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
Post-translational modifications
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation.
Phosphorylated; triggering degradation by the proteasome.
Sequence Similarities
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Tissue Specificity
Isoform 2
Seems to be less widely expressed than isoform 1.
Alternative names
TPH, TPRH, TRPH, TPH1, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1