Tryptophan Hydroxylase/TPH

Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.

Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.

Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation.

Phosphorylated; triggering degradation by the proteasome.

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Isoform 2

Seems to be less widely expressed than isoform 1.

TPH, TPRH, TRPH, TPH1, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1

• entrezGene:7166
• omim:191060
• swissprot:P17752

Proteins

Neuroscience

50985Da