TPM1

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Sequence Similarities

Belongs to the tropomyosin family.

Cellular localization

• Cytoplasm
• Cytoskeleton
• Associates with F-actin stress fibers.

Alternative names

Tropomyosin alpha-1 chain, Alpha-tropomyosin, Tropomyosin-1, TPM1

Database links

swissprot:P04268 entrezGene:396430 swissprot:P19352 entrezGene:396366