TPMT

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748, PubMed:657528). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.

• Cytoplasm

Thiopurine S-methyltransferase, Thiopurine methyltransferase, TPMT

• entrezGene:7172
• omim:187680
• swissprot:P51580

Proteins

Cardiovascular

28180Da