TPO

Function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Involvement in disease

An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.

Thyroid dyshormonogenesis 2A

TDH2A

A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.

None

The disease is caused by variants affecting the gene represented in this entry.

Pathway

Hormone biosynthesis; thyroid hormone biosynthesis.

Post-translational modifications

Glycosylated.

Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.

Cleaved in its N-terminal part.

Sequence similarities

Belongs to the peroxidase family. XPO subfamily.

Cellular localization

• Membrane
• Single-pass type I membrane protein
• Isoform 3
• Cell surface

Alternative names

• Thyroid peroxidase
• TPO
• TPO

Database links

• entrezGene:7173
• omim:606765
• swissprot:P07202

Target type

Proteins

Molecular weight

102963Da