TPST1
Function
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the protein sulfotransferase family.
Tissue Specificity
Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Cellular localization
- Golgi apparatus membrane
- Single-pass type II membrane protein
Alternative names
Protein-tyrosine sulfotransferase 1, Tyrosylprotein sulfotransferase 1, TPST-1, TPST1