TRAF3IP2

Function

E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828).

Involvement in disease

Psoriasis 13

PSORS13

A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Candidiasis, familial, 8

CANDF8

A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

None

The disease is caused by variants affecting the gene represented in this entry.

Tissue specificity

Widely expressed.

Alternative names

• E3 ubiquitin ligase TRAF3IP2
• Adapter protein CIKS
• Connection to IKK and SAPK/JNK
• E3 ubiquitin-protein ligase CIKS
• Nuclear factor NF-kappa-B activator 1
• TRAF3-interacting protein 2
• ACT1
• TRAF3IP2
• C6orf2
• C6orf6
• C6orf4
• C6orf5

Database links

• entrezGene:10758
• omim:607043
• swissprot:O43734

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Molecular weight

64666Da