TRAF5
Domain
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Function
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Post-translational modifications
Ubiquitinated at Lys-318 by the SCF(FBXL2) complex, leading to its degradation by the proteasome.
Sequence Similarities
Belongs to the TNF receptor-associated factor family. A subfamily.
Tissue Specificity
Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytosol
Alternative names
RNF84, TRAF5, TNF receptor-associated factor 5, RING finger protein 84