Transcription factor AP-2 gamma

The PPxY motif mediates interaction with WWOX.

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Sumoylated on Lys-10; which inhibits transcriptional activity.

Belongs to the AP-2 family.

• Nucleus

Transcription factor AP-2 gamma, AP2-gamma, Activating enhancer-binding protein 2 gamma, Transcription factor ERF-1, TFAP2C

• entrezGene:7022
• omim:601602
• swissprot:Q92754

Proteins

Epigenetics

49177Da