Transcription factor jun-B

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity).

Ubiquitinated by ITCH, leading to its degradation.

Belongs to the bZIP family. Jun subfamily.

• Nucleus

Transcription factor JunB, Transcription factor AP-1 subunit JunB, JUNB

• entrezGene:3726
• omim:165161
• swissprot:P17275

Proteins

Oncology

35879Da