Transcription regulator protein BACH1
Function
Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).
Post-translational modifications
Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.
Sequence Similarities
Belongs to the bZIP family. CNC subfamily.
Cellular localization
- Nucleus
Alternative names
Transcription regulator protein BACH1, BTB and CNC homolog 1, HA2303, BACH1