Transcriptional repressor p66-alpha
Domain
Both CR1 and CR2 regions are required for speckled nuclear localization.
Function
Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179).
Tissue Specificity
Ubiquitous, both in fetal and adult tissues.
Cellular localization
- Nucleus speckle
- Nucleus
- Chromosome
- Speckled nuclear localization requires both CR1 and CR2 regions (PubMed:16415179). Localizes to sites of DNA damage in a manner partially dependent on ZMYND8 (PubMed:27732854).
Alternative names
Transcriptional repressor p66-alpha, Hp66alpha, GATA zinc finger domain-containing protein 2A, GATAD2A