TPT1

Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344).

Belongs to the TCTP family.

Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.

• Cytoplasm

Translationally-controlled tumor protein, TCTP, Fortilin, Histamine-releasing factor, p23, HRF, TPT1

• entrezGene:7178
• omim:600763
• swissprot:P13693

Proteins

Oncology

19595Da