TRARG1
Developmental stage
Expressed in fetal brain.
Function
Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.
Sequence Similarities
Belongs to the CD225/Dispanin family.
Tissue Specificity
Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404).
Cellular localization
- Cell membrane
- Single-pass membrane protein
- Endomembrane system
- Single-pass membrane protein
- Cytoplasm
- Perinuclear region
- Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation.
Alternative names
IFITMD3, LOST1, TUSC5, TRARG1, Trafficking regulator of GLUT4 1, Dispanin subfamily B member 1, Interferon-induced transmembrane domain-containing protein D3, Protein located at seventeen-p-thirteen point three 1, Tumor suppressor candidate 5, DSPB1