TRAT1
Developmental stage
Strongly expressed in fetal thymus at weeks 17-24 of gestation. Undetectable in bone marrow and fetal liver.
Function
Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.
Post-translational modifications
Phosphorylated on tyrosines by LCK or FYN upon TCR activation.
Tissue Specificity
Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level).
Cellular localization
- Cell membrane
- Single-pass type III membrane protein
Alternative names
TCRIM, HSPC062, TRAT1, T-cell receptor-associated transmembrane adapter 1, T-cell receptor-interacting molecule, pp29/30, TRIM