TRIM16
Function
E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
Post-translational modifications
Phosphorylated by ULK1.
Auto-ubiquitinates via its B-Boxes.
Sequence Similarities
Belongs to the TRIM/RBCC family.
Tissue Specificity
Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.
Cellular localization
- Cytoplasm
Alternative names
EBBP, TRIM16, Tripartite motif-containing protein 16, E3 ubiquitin-protein ligase TRIM16, Estrogen-responsive B box protein