TRIM29
Function
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Post-translational modifications
Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
Tissue Specificity
Expressed in placenta, prostate and thymus.
Cellular localization
- Cytoplasm
- Lysosome
- Colocalizes with intermediate filaments.
Alternative names
ATDC, TRIM29, Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein