Trim30a
Function
Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.
Tissue Specificity
Highly expressed in spleen and lymph nodes (at protein level).
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
Rpt-1, Rpt1, Trim30, Trim30a, Tripartite motif-containing protein 30A, Down regulatory protein of interleukin-2 receptor, Tripartite motif-containing protein 30