TRIM39
Function
Isoform 1
E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).
Isoform 2
Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251). Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554).
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Autoubiquitinated.
Sequence Similarities
Belongs to the TRIM/RBCC family.
Tissue Specificity
Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
Cellular localization
- Isoform 1
- Cytoplasm
- Cytosol
- Mitochondrion
- Nucleus
- Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus.
- Isoform 2
- Nucleus
- Colocalizes with CDKN1A in the nucleus.
Alternative names
RNF23, TFP, TRIM39, E3 ubiquitin-protein ligase TRIM39, RING finger protein 23, RING-type E3 ubiquitin transferase TRIM39, Testis-abundant finger protein, Tripartite motif-containing protein 39