TRIM45
Developmental stage
Expressed in brain, lung, skeletal muscle, heart and intestine in 80-day old embryo.
Function
E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response (PubMed:36681779). May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.
Sequence Similarities
Belongs to the TRIM/RBCC family.
Tissue Specificity
Expressed in skeletal muscle, brain, heart and pancreas.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
RNF99, TRIM45, E3 ubiquitin-protein ligase TRIM45, RING finger protein 99