Tripartite motif-containing protein 46

Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.

Belongs to the TRIM/RBCC family.

• Cell projection
• Axon
• Cytoplasm
• Cytoskeleton
• Microtubule-associated. Localizes to the proximal part of the axon.

TRIFIC, TRIM46, Tripartite motif-containing protein 46, Gene Y protein, GeneY

• entrezGene:80128
• omim:600986
• swissprot:Q7Z4K8

Proteins

Neuroscience

83424Da