TRIM58
Domain
The RING finger is required for ubiquitin ligase activity.
Function
E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the TRIM/RBCC family.
Tissue Specificity
Expressed in erythroblasts.
Alternative names
E3 ubiquitin-protein ligase TRIM58, Protein BIA2, RING-type E3 ubiquitin transferase TRIM58, Tripartite motif-containing protein 58, TRIM58