TRIM68
Domain
The RING domain is essential for ubiquitin E3 ligase activity.
Function
Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Auto-ubiquitinated.
Sequence Similarities
Belongs to the TRIM/RBCC family.
Tissue Specificity
Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.
Cellular localization
- Cytoplasm
- Perinuclear region
- Nucleus
- Colocalized with AR in nucleus.
Alternative names
GC109, RNF137, SS56, TRIM68, E3 ubiquitin-protein ligase TRIM68, RING finger protein 137, RING-type E3 ubiquitin transferase TRIM68, SSA protein SS-56, Tripartite motif-containing protein 68, SS-56