TRIOBP
Domain
Contains at least 2 actin-binding sites per coiled-coil dimer.
Function
Isoform 1
Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559).
Isoform 5
Plays a pivotal role in the formation of stereocilia rootlets.
Isoform 4
Plays a pivotal role in the formation of stereocilia rootlets.
Involvement in disease
Deafness, autosomal recessive, 28
DFNB28
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Isoform 1
Ubiquitinated by HECTD3, leading to its degradation by the proteasome.
Isoform 1
Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation (PubMed:22820163). Phosphorylation at residues Thr-221 and Thr-457 by kinase NEK2A and PLK1 coordinates TERF1 translocation from telomere to spindle pole (PubMed:24692559).
Tissue Specificity
Isoform 1
Widely expressed. Highly expressed in heart and placenta.
Isoform 3
Expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.
Cellular localization
- Nucleus
- Isoform 1
- Nucleus
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Midbody
- Chromosome
- Telomere
- Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.
Alternative names
KIAA1662, TARA, HRIHFB2122, TRIOBP, TRIO and F-actin-binding protein, Protein Tara, TRF1-associated protein of 68 kDa, Trio-associated repeat on actin