TRIP10
Domain
The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation.
Function
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
Post-translational modifications
Tyrosine phosphorylated. Also phosphorylated by PKA.
Sequence Similarities
Belongs to the FNBP1 family.
Tissue Specificity
Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Cell cortex
- Lysosome
- Golgi apparatus
- Cell membrane
- Cell projection
- Phagocytic cup
- Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.
- Isoform 5
- Cytoplasm
- Perinuclear region
Alternative names
CIP4, STOT, STP, TRIP10, Cdc42-interacting protein 4, Protein Felic, Salt tolerant protein, Thyroid receptor-interacting protein 10, hSTP, TR-interacting protein 10, TRIP-10