TRMT1

Function

Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

Involvement in disease

Intellectual developmental disorder, autosomal recessive 68

MRT68

A form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence Similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

Alternative names

tRNA (guanine(26)-N(2))-dimethyltransferase, TRMT1

Database links

swissprot:Q9NXH9 omim:610230 entrezGene:55687 entrezGene:55621 swissprot:O75648 omim:611669