TRMT2A
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281).
Sequence Similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Cellular localization
- Cytoplasm
- Cytosol
Alternative names
tRNA (uracil-5-)-methyltransferase homolog A, mRNA (uracil-5-)-methyltransferase TRMT2A, TRMT2A