TRPC1
Function
Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Also activated by intracellular calcium store depletion.
Isoform Short
Forms a receptor-activated non-selective calcium permeant cation channel. Also activated by intracellular calcium store depletion.
Post-translational modifications
Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.
Sequence Similarities
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
Tissue Specificity
Seems to be ubiquitous.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
TRP1, TRPC1, Short transient receptor potential channel 1, TrpC1, Transient receptor protein 1, TRP-1