TRPC7
Function
Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.
Post-translational modifications
Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.
Sequence Similarities
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Nucleus envelope
Alternative names
TRP7, TRPC7, Short transient receptor potential channel 7, TrpC7, Transient receptor protein 7, TRP-7, hTRP7