Trpv2
Function
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).
Post-translational modifications
N-glycosylated.
Phosphorylated by PKA.
Sequence Similarities
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
Tissue Specificity
Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal cord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level).
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cytoplasm
- Melanosome
- Translocates from the cytoplasm to the plasma membrane upon ligand stimulation.
Alternative names
Sac2b, Vrl1, Transient receptor potential cation channel subfamily V member 2, TrpV2, Osm-9-like TRP channel 2, Stretch-activated channel 2B, Vanilloid receptor-like protein 1, OTRPC2, VRL-1