TRPV2
Function
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
Post-translational modifications
N-glycosylated.
Phosphorylated by PKA.
Sequence Similarities
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cytoplasm
- Melanosome
- Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Alternative names
VRL, TRPV2, Transient receptor potential cation channel subfamily V member 2, TrpV2, Osm-9-like TRP channel 2, Vanilloid receptor-like protein 1, OTRPC2, VRL-1