TSGA10
Function
Plays a role in spermatogenesis (PubMed:28905369). When overexpressed, prevents nuclear localization of HIF1A (By similarity).
Involvement in disease
Spermatogenic failure 26
SPGF26
An autosomal recessive infertility disorder caused by spermatogenesis defects that result in acephalic spermatozoa.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments.
Sequence Similarities
Belongs to the CEP135/TSGA10 family.
Tissue Specificity
Expressed in the testis, in spermatozoa (at protein level) (PubMed:11179690, PubMed:28905369). Expressed in actively dividing fetal tissues, including sternum, intestine, limb, kidney and stomach (PubMed:14585816).
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Centriole
- In mature spermatozoa, localizes to the centriole and midpiece (PubMed:28905369). The 27-kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail, while the 55-kDa peptide localizes to the midpiece (By similarity). Detected in the cytoplasm of almost all spermatogonial cells within the seminiferous tubules (By similarity).
Alternative names
CEP4L, TSGA10, Testis-specific gene 10 protein, Testis development protein NYD-SP7