Tshr
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Involvement in disease
Defects in Tshr are the cause of hyt/hyt hypothyroidism, an autosomal recessive, fetal-onset, severe hypothyroidism related to TSH hyporesponsiveness and associated with elevated TSH.
Post-translational modifications
Glycosylated.
Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Basolateral cell membrane
- Multi-pass membrane protein
Alternative names
Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, Tshr