Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Defects in Tshr are the cause of hyt/hyt hypothyroidism, an autosomal recessive, fetal-onset, severe hypothyroidism related to TSH hyporesponsiveness and associated with elevated TSH.
Glycosylated.
Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation.
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, Tshr
Proteins
Cardiovascular
86583Da
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