TSLP
GeneName
TSLP
Summary
TSLP, also known as thymic stromal lymphopoietin or hTSLP, is an 18kDa cytokine that is secreted into the extracellular region and space. It plays a vital role in immune responses, particularly in the activation and regulation of T cells and other immune cells. TSLP binds to the interleukin-7 receptor, initiating signalling pathways that involve JAK-STAT, and is involved in various biological processes including the defence response to pathogens such as fungi and Gram-negative bacteria. Additionally, it positively regulates the production of several cytokines and chemokines, influencing inflammatory responses and cell proliferation.
Importance
TSLP is relevant to: - Allergic diseases, including asthma, due to its role in promoting Th2 cell differentiation and cytokine production. - Chronic inflammatory conditions, as it influences mast cell activation and cytokine-mediated signalling pathways. - Immune responses to infections, particularly in the context of defence against fungal and bacterial pathogens. - Cancer research, where its modulation of immune responses may impact tumour progression and the effectiveness of immunotherapies.
Top Products
For researchers investigating TSLP, we recommend the well-cited polyclonal antibody, Anti-TSLP antibody (ab47943). This antibody has garnered 34 citations, reflecting its reliability and trust within the scientific community. It is particularly effective for Western blotting (WB) and ELISA applications, making it a versatile choice for various experimental needs. This product is an excellent option for those looking to study TSLP with a proven track record in the field. The Human TSLP ELISA Kit (ab192149), supported by 1 citation, is a reliable option for researchers looking to measure TSLP levels in their samples.
Abcam Product Citation Summary
The data indicates that TSLP is being studied in various contexts related to inflammation, particularly in the lungs and skin. The use of Abcam antibodies in both mouse and human tissues highlights the relevance of TSLP in airway hyperresponsiveness, asthma, and skin inflammation. The studies suggest a significant role for TSLP in inflammatory responses, with multiple applications in Western blotting and immunohistochemistry.
Abcam Product Citation Table
Function
Isoform 1
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
Isoform 2
May act as an antimicrobial peptide in the oral cavity and on the skin.
Tissue Specificity
Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.
Cellular localization
- Secreted
Alternative names
Thymic stromal lymphopoietin, TSLP