TSPAN33
Function
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:26686862, PubMed:30463011, PubMed:37516108). Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011).
Sequence Similarities
Belongs to the tetraspanin (TM4SF) family.
Tissue Specificity
Predominantly expressed in erythroblasts.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cell junction
- Adherens junction
- Cytoplasm
- Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction.
Alternative names
PEN, TSPAN33, Tetraspanin-33, Tspan-33, Penumbra, Proerythroblast new membrane, hPen