PBR

In erythrocytes, expression levels decrease throughout differentiation (PubMed:27641616). Not expressed in mature erythrocytes (PubMed:27641616).

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).

Belongs to the TspO/BZRP family.

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.

• Mitochondrion membrane
• Multi-pass membrane protein

BZRP, MBR, TSPO, Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral-type benzodiazepine receptor, PBR

• entrezGene:706
• omim:109610
• swissprot:P30536
• swissprot:B1AH88

Proteins

Neuroscience

• Cardiovascular