Tspo

Function

Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis (By similarity). Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:2555358).

Post-translational modifications

The N-terminus is blocked.

Sequence Similarities

Belongs to the TspO/BZRP family.

Tissue Specificity

Highly expressed in adrenal gland.

Cellular localization

• Mitochondrion membrane
• Multi-pass membrane protein
• Membrane
• Multi-pass membrane protein

Alternative names

Bzrp, Mbr, Tspo, Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral-type benzodiazepine receptor, PBR

Database links

swissprot:P16257 entrezGene:24230

Other research areas

• Cardiovascular