Tspo

Function

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060).

Sequence Similarities

Belongs to the TspO/BZRP family.

Tissue Specificity

Detected in liver (at protein level). Ubiquitous.

Cellular localization

• Mitochondrion membrane
• Multi-pass membrane protein
• Membrane
• Multi-pass membrane protein

Alternative names

Bzrp, Mbr, Tspo, Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral-type benzodiazepine receptor, PBR

Database links

swissprot:P50637 entrezGene:12257

Other research areas

• Cardiovascular