TSPY1

Developmental stage

Detected in 22-week old testis.

Function

May be involved in sperm differentiation and proliferation.

Involvement in disease

TSPY is located in the gonadoblastoma critical region and is preferentially expressed in tumor germ cells of gonadoblastoma specimens. Expression also correlates with testicular seminoma and tumorigenesis of the prostate gland.

Post-translational modifications

Phosphorylated.

Sequence Similarities

Belongs to the nucleosome assembly protein (NAP) family.

Tissue Specificity

Specifically expressed in testicular tissues. Isoform 1 and isoform 2 are expressed in spermatogonia and spermatocytes. Found in early testicular carcinoma in situ, spermatogonial cells in testicular tissues of 46,X,Y female and in prostate cancer cell lines.

Cellular localization

• Cytoplasm
• Nucleus
• Predominantly cytoplasmic. Also found in nucleus.

Alternative names

TSPY, TSPY1, Testis-specific Y-encoded protein 1, Cancer/testis antigen 78, CT78

Database links

swissprot:Q01534 entrezGene:100289087 entrezGene:728137 entrezGene:7258 omim:480100